| Name | Pos. | Injury | Practice status | Game status |
|---|---|---|---|---|
| Duane Brown | OT | Shoulder | DNP | out |
| Brandin Echols | CB | Quadriceps | DNP | out |
| George Fant | OT | Knee | DNP | out |
| Lamarcus Joyner | S | Hip | DNP | out |
| Nate Herbig | G | Calf | DNP | out |
| Laurent Duvernay-Tardif | G | Knee | LP | questionable |
| Jordan Whitehead | FS | Hamstring | LP | questionable |
| Mike White | QB | Rib | LP | questionable |
| Ashtyn Davis | SAF | Ankle | LP | questionable |
| C.J. Uzomah | TE | Ankle | DNP | questionable |
| Vinny Curry | DE | Biceps | FP | probable |
| C.J. Mosley | ILB | Shoulde | FP | probable |