| Name | Pos. | Injury | Practice status | Game status |
|---|---|---|---|---|
| Sauce Gardner | CB | Hamstring | DNP | out |
| Leki Fotu | DT | Knee | FP | out |
| Tyler Conklin | TE | Calf | LP | questionable |
| Morgan Moses | OT | Knee | DNP | questionable |
| Alijah Vera-Tucker | G | Ankle | LP | questionable |
| Quinnen Williams | DL | Hamstring | DNP | questionable |
| John Simpson | OL | Groin | FP | probable |
| Malachi Corley | WR | Elbow | FP | probable |
| Haason Reddick | OLB | Neck | FP | probable |
| Chazz Surratt | LB | Ankle | FP | probable |